selected publications
Fondevila MF*#, Novoa E, Fernandez U, Dorta V, Parracho T, Kreimeyer H, Garcia-Vence M, Chantada-Vazquez MP, Bravo SB, Porteiro B, Cabaleiro A, Koning M, Senra A, Souto Y, Verheij J, Guallar D, Fidalgo M, Meijnikman AS, da Silva Lima N, Dieguez C, Gonzalez-Rellan MJ, Nogueiras R#. Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice. Molecular Metabolism. 2024 May 28. doi: 10.1016/j.molmet.2024.101962. In Press, Journal Pre-proof
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Nóvoa E*, da Silva Lima N*, Gonzalez-Rellan MJ, Chantada-Vazquez MDP, Verheij J, Rodriguez A, Esquinas-Roman EM, Fondevila MF, Koning M, Fernandez U, Cabaleiro A, Parracho T, Iglesias-Moure J, Seoane S, Porteiro B, Escudero A, Senra A, Perez-Fernandez R, López M, Fidalgo M, Guallar D, Martinez-Chantar ML, Dieguez C, Varela-Rey M, Prevot V, Schwaninger M, Meijnikman A, Bravo SB, Frühbeck G, Nogueiras R. Mitochondrial antiviral signaling protein enhances MASLD progression via the ERK/TNFα/NFκβ pathway. Hepatology. 2024 May 16. doi: 10.1097/HEP.0000000000000930. Online ahead of print
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Wu Q*, Carlos AR*, Braza F*, Bergman ML, Kitoko JZ, Bastos-Amador P, Cuadrado E, Martins R, Oliveira BS, Martins VC, Scicluna BP, Landry JJ, Jung FE, Ademolue TW, Peitzsch M, Almeida-Santos J, Thompson J, Cardoso S, Ventura P, Slot M, Rontogianni S, Ribeiro V, Domingues VDS, Cabral IA, Weis S, Groth M, Ameneiro C, Fidalgo M, Wang F, Demengeot J, Amsen D, Soares MP. Ferritin heavy chain supports stability and function of the regulatory T cell lineage. EMBO J. 2024 Mar 18. doi: 10.1038/s44318-024-00064-x.
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Fernandez-Rial C, Fidalgo M#. Induction of Transient Morula-Like Cells in Mice Through STAT3 Activation. Cell Reprogram. 2024 Jan 31. doi: 10.1089/cell.2023.0116
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Capelo-Diz A*, Lachiondo-Ortega S*, Fernández-Ramos D*, Cañas-Martín J*, Goikoetxea-Usandizaga N, Serrano-Maciá M, González-Rellan MJ, Mosca L, Blazquez-Vicens J, Tinahones-Ruano A, Fondevila MF, Buyan M, Delgado TC, Gutierrez de Juan V, Ayuso-García P, Sánchez-Rueda A, Velasco-Avilés S, Fernández-Susavila H, Riobello-Suárez C, Dziechciarz B, Montiel-Duarte C, Lopitz-Otsoa F, Bizkarguenaga M, Bilbao-García J, Bernardo-Seisdedos G, Senra A, Soriano-Navarro M, Millet O, Díaz-Lagares A, Crujeiras AB, Bao-Caamano A, Cabrera D, van Liempd S, Tamayo-Carro M, Borzacchiello L, Gomez-Santos B, Buqué X, Sáenz de Urturi D, González-Romero F, Simon J, Rodríguez-Agudo R, Ruiz A, Matute C, Beiroa D, Falcon-Perez JM, Aspichueta P, Rodríguez-Cuesta J, Porcelli M, Pajares MA, Ameneiro C, Fidalgo M, Aransay AM, Lama-Díaz T, Blanco MG, López M, Villa-Bellosta R, Müller TD, Nogueiras R, Woodhoo A, Martínez-Chantar ML#, Varela-Rey M#. Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting. Cell Metabolism. 2023 Jul 31; doi: 10.1016/j.cmet.2023.07.002
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Gonzalez-Rellan MJ*#, Parracho T*, Heras V, Rodriguez A, Fondevila MF, Novoa E, Lima N, Varela-Rey M, Senra A, Chantada-Vazquez MDP, Ameneiro C, Bernardo G, Fernandez-Ramos D, Lopitz-Otsoa F, Bilbao J, Guallar D, Fidalgo M, Bravo S, Dieguez C, Martinez-Chantar ML, Millet O, Mato JM, Schwaninger M, Prevot V, Crespo J, Frühbeck G, Iruzubieta P, Nogueiras R#. Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function. Molecular Metabolism. 2023 Jul 23; doi: 10.1016/j.molmet.2023.101776.
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Fidalgo M#, Guallar D, and Pereira CF. Reprogramming Stars #11: Teaming Up to Uncover the Epitranscriptomics of Reprogramming-An Interview with Dr. Miguel Fidalgo and Dr. Diana Guallar. Cell Reprogramm. 2023 Apr 25; doi: 10.1089/cell.2023.0024.
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Malik V*, Zang R*, Fuentes-Iglesias A, Huang X, Li D, Fidalgo M, Zhou H, and Wang J. Comparative functional genomics identifies unique molecular features of EPSCs. Life Science Alliance. 2022 Aug 12; doi: 10.26508/lsa.202201608
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Pena-Leon V*, Folgueira C*, Barja-Fernández S*, Pérez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, González-Saenz P, Vázquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, López M, Tovar S, Casanueva FF, Valjent E, Diéguez C, Prevot V, Nogueiras R#, Seoane LM#. Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21. Nature Metabolism. 2022 Jul 25; doi: 10.1038/s42255-022-00602-z
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Gonzalez-Rellan MJ*, Novoa E*, da Silva Lima N, Rodriguez A, Veyrat-Durebex C, Seoane S, Porteiro B, Fondevila MF, Fernandez U, Varela-Rey M, Senra A, Iglesias C, Escudero A, Fidalgo M, Guallar D, Perez-Fernandez R, Prevot V, Schwaninger M, López M, Dieguez C, Coppari R, Frühbeck G, Nogueiras R. Hepatic p63 regulates glucose metabolism by repressing SIRT1. Gut. 2022 May 17; doi: 10.1136/gutjnl-2021-326620.
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da Silva Lima N*, Fondevila MF*, Nóvoa E*, Buqué X, Mercado-Gómez M, Gallet S, González-Rellan MJ, Fernandez U, Loyens A, Garcia-Vence M, Chantada-Vazquez MDP, Bravo SB, Marañon P, Senra A, Escudero A, Leiva M, Guallar D, Fidalgo M, Gomes P, Claret M, Sabio G, Varela-Rey M, Delgado TC, Montero-Vallejo R, Ampuero J, López M, Diéguez C, Herrero L, Serra D, Schwaninger M, Prevot V, Gallego-Duran R, Romero-Gomez M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Garcia-Monzon C, Gonzalez-Rodriguez A, Aspichueta P, Nogueiras R. Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function. Journal of Hepatology. 2022 Jan 01; doi: 10.1016/j.jhep.2021.09.008. Epub 2021 Sep 21
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Covelo-Molares H*, Souto Y*, Fidalgo M, Guallar D. A Simple, Rapid, and Cost-Effective Method for Loss-of-Function Assays in Pluripotent Cells. Methods Mol Biol.. 2021 Oct 06; doi: 10.1007/7651_2021_434
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Gonzalez-Rellan MJ, Fondevila MF*, Fernandez U*, Rodríguez A, Varela-Rey M, Veyrat-Durebex C, Seoane S, Bernardo G, Lopitz-Otsoa F, Fernández-Ramos D, Bilbao J, Iglesias C, Novoa E, Ameneiro C, Senra A, Beiroa D, Cuñarro J, Chantada-Vazquez MDP, Garcia-Vence M, Bravo SS, Da Silva Lima N, Porteiro B, Carneiro C, Vidal A, Tovar S, Müller TD, Ferno J, Guallar D, Fidalgo M, Sabio G, Herzig S, Yang WH, Cho JW, Martinez-Chantar ML, Perez-Fernandez R, López M, Dieguez C, Mato JM, Millet O, Coppari R, Woodhoo A, Fruhbeck G, Nogueiras R. O-GlcNAcylated p53 in the liver modulates hepatic glucose production. Nature Communications.. 2021 Aug 20; doi:10.1038/s41467-021-25390-0
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Wang Y*, Yu H*, Ma Q*, Zeng P, Wu D, Hou Y, Liu X, Jia L, Sun J, Chen Y, Guallar D, Fidalgo M, Chen J, Yu Y, Jiang S, Li F, Zhao C, Huang X, Wang J, Li C, Sun Y, Zeng X, Zhang W, Miao Y, Ding J. Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions. Cell Stem Cell.. 2021 May 25; doi:10.1016/j.stem.2021.04.023
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Fuentes-Iglesias A*, Ameneiro C*, Guallar D, Fidalgo M. Detecting and Modulating ER Stress to Improve Generation of Induced Pluripotent Stem Cells. Methods Mol Biol.. 2021 Mar 11; doi:10.1007/7651_2021_354
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Garcia-Outeiral V, De La Parte C, Fidalgo M, Guallar D. The complexity of TET2 functions in pluripotency and development. Front. Cell Dev. Biol. 2021 January 18; doi:10.3389/fcell.2020.630754
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Lan J, Rajan N, Bizet M, Penning A, Singh NK, Guallar D, Calonne E, Li Greci A, Bonvin E, Deplus R, Hsu PJ, Nachtergaele S, Ma C, Song R, Fuentes-Iglesias A, Hassabi B, Putmans P, Mies F, Menschaert G, Wong JJL, Wang J, Fidalgo M, Yuan B, Fuks F. Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nature Communications 2020 October 02; doi:10.1038/s41467-020-18729-6
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Fuentes-Iglesias A, Garcia-Outeiral V, Pardavila JA, Wang J#, Fidalgo M#, Guallar D#. An optimized immunoprecipitation protocol for assessing protein-RNA interactions in vitro. STAR Protocols. 2020 September 04; doi: 10.1016/j.xpro.2020.100093
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Guallar D*#, Fuentes-Iglesias A*, Souto Y, Ameneiro C, Freire-Agulleiro O, Pardavila JA, Saenz C, Escudero A, Garcia-Outeiral V, Xiong H, Moreira T, Liu D, Xiao S, Hou Y, Wu K, Torrecilla D, Hartner JC, Blanco MG, Lee LJ, López M, Walkley CR, Wang J#, Fidalgo M#. ADAR1-dependent RNA editing promotes MET and iPSC reprogramming by alleviating ER stress. Cell Stem Cell 2020 May 11; doi: 10.1016/j.stem.2020.04.016
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Fondevila MF, Fernandez U*, Gonzalez-Rellan MJ*, Da Silva Lima N*, Buque X*, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R. The L-α-lysophosphatidylinositol/GPR55 system induces the development of non-alcoholic steatosis and steatohepatitis. Hepatology. 2020 Apr 23; doi: 10.1002/hep.31290
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Ameneiro C, Moreira T, Fuentes-Iglesias A, Coego A, Garcia-Outeiral V, Escudero A, Torrecilla D, Mulero-Navarro S, Carvajal-Gonzalez JM, Guallar D#, Fidalgo M#. BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells. Life Science Alliance. 2020 Apr 13; http://doi.org/10.26508/lsa.201900534
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Yang F*, Huang X*, Zang R*, Chen J, Fidalgo M, Sanchez-Priego C, Yang J, Caichen A, Ma F, Macfarlan T, Wang H, Gao S, Zhou H, and Wang J. DUX-miR-344-ZMYM2-mediated activation of MERVL LTRs induces a totipotent 2C-like state. Cell Stem Cell. 2020 Jan 04; doi: 10.1016/j.stem.2020.01.004
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Al-Massadi O, Quiñones M, Clasadonte J, Bautista RH, Romero-Picó A, Folgueira C, Morgan DA, Kalló I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, García-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity and Glucose Intolerance. Diabetes 2019 Sep 16; doi: 10.2337/db19-0029.
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Woo, A. J., Patry, C.-A. A., Ghamari, A., Pregernig, G., Yuan, D., Zheng, K., Piers, T., Hibbs, M., Li, J., Fidalgo, M., Wang, J. Y., Lee, J.-H., Leedman, P. J., Wang, J., Fraenkel, E., Cantor, A. B. Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood Advances 2019 Aug 27; doi: 10.1182/bloodadvances.2018030551
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Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal, Fondevila MF, Barja-Fernández S, Gallego R, Hernández-Bautista, Castelao C, Senra A, Seoane-Collazo P, Gomez-Lado N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-Garcia JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Frübeck G, Seoane LM, Nogueiras R. Hypothalamic dopamine signalling regulates brown fat thermogenesis. Nature Metabolism 2019 Aug 19; doi: 10.1038/s42255-019-0099-7
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Seoane-Collazo P, Roa J, Rial-Pensado E, Liñares-Pose L, Beiroa D, Ruíz-Pino F, Lopez-Gonzalez T, Morgan DA, Pardavila JA, Sanchez-Tapia MJ, Martínez-Sánchez N, Contreras C, Fidalgo M, Dieguez C, Coppari R, Rahmouni K, Nogueiras R, Tena-Sempere M, Lopez M. . SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity. Diabetes 2018 Aug 13; doi: 10.2337/db17-1538
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Guallar D and Fidalgo M. New mechanisms of epigenetic regulation through the cell identity regulator TET2. Genetica Medica News 2018 Apr 03. Vol 99. ISSN 2386-5113
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Guallar D, Bi X*, Pardavila JA*, Huang X*, Saenz C, Shi X, Zhou H, Faiola F, Ding J, Haruehanroengra P, Yang F, Li D, Sanchez-Priego C, Saunders A, Pan F, Valdes VJ, Kelley K, Blanco MG, Chen L, Wang H, Sheng J, Xu M, Fidalgo M, Shen X, Wang J. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells. Nature Genetics 2018 Feb 26; doi: 10.1038/s41588-018-0060-9
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Wang J*, Wu X*, Wei C*, Huang X, Ma Q, Huang X, Faiola F, Guallar D, Fidalgo M, Huang T, Peng D, Chen L, Yu H, Li X, Sun J, Liu X, Cai X, Chen, Wang L, Ren J, Wang J#, Ding J#. (2018). YY1 positively regulates transcription by targeting promoters and super-enhancers through the BAF complex in embryonic stem cells. Stem Cell Reports. 2018 Feb 26; doi: 10.1016/j.stemcr.2018.02.004.
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Zhang Y*, Xian Y*, Yin Q*, Du Z*, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu J, Wang J, Li L, Xie W. Dynamic epigenomic landscapes during early lineage specification in mouse embryos. Nature Genetics 2018 Jan; doi: 10.1038/s41588-017-0003-x
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Huang X*, Balmer S*, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis A-K#, Wang J#. Zfp281 is essential for mouse epiblast maduration through transcriptional and epigenetic control of Nodal signaling. eLife 2017 Nov; doi: 10.7554/eLife.33333
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Faiola F*#, Yin N*, Fidalgo M, Huang X, Ding J, Guallar D, Dang B, Wang J#. NAC1 regulates somatic cell reprogramming by controlling Zeb1 and E-cadherin expression. Stem Cell Reports, 2017 Jul 24; doi: 10.1016/j.stemcr.2017.07.002
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Saunders A*, Li D*, Faiola F, Huang X, Fidalgo M, Guallar D, Ding J, Yang F, Xu Y, Zhou H, Wang J. Context-dependent functions of Nanog phosphorylation in pluripotency and reprogramming. Stem Cell Reports. 2017 Apr 18; doi: 10.1016/j.stemcr.2017.03.023
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Saunders A, Huang X, Fidalgo M, Reimer MH Jr, Faiola F, Ding J, Sánchez-Priego C, Guallar D, Saenz C, Li D, Wang J. The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency. Cell Reports. 2017 Feb 14; doi: 10.1016/j.celrep.2017.01.055
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Fidalgo M, Huang X, Guallar D, Sanchez-Priego C, Valdes VJ, Saunders A, Ding J, Wu WS, Clavel C, Wang J. Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States. Cell Stem Cell. 2016 Sep; doi: 10.1016/j.stem.2016.05.025
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Aguilo F, Zhang F, Sancho A, Fidalgo M, Di Cecilia S, Vashisht A, Lee DF, Chen CH, Rengasamy M, Andino B, Jahouh F, Roman A, Krig SR, Wang R, Zhang W, Wohlschlegel JA, Wang J, Walsh MJ. Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming. Cell Stem Cell. 2015 Dec 3; doi: 10.1016/j.stem.2015.09.005
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Ding J, Huang X, Shao N, Zhou H, Lee DF, Faiola F, Fidalgo M, Guallar D, Saunders A, Shliaha PV, Wang H, Waghray A, Papatsenko D, Sánchez-Priego C, Li D, Yuan Y, Lemischka IR, Shen L, Kelley K, Deng H, Shen X, Wang J. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Cell Stem Cell. 2015 Jun 4; doi: 10.1016/j.stem.2015.04.001
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Gingold JA*, Fidalgo M*, Guallar D, Lau Z, Sun Z, Zhou H, Faiola F, Huang X, Lee DF, Waghray A, Schaniel C, Felsenfeld DP, Lemischka IR#, Wang J#. A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Molecular Cell. 2014 Oct; doi: 10.1016/j.molcel.2014.08.014
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Costa Y*, Ding J*, Theunissen TW*, Faiola F*, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S, Levasseur DN, Li Z, Xu M, Reik W, Silva JC#, Wang J#. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013 Mar 21; doi: 10.1038/nature11925
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MacArthur BD*, Sevilla A*, Lenz M, Müller FJ, Schuldt BM, Schuppert AA, Ridden SJ, Stumpf PS, Fidalgo M, Ma'ayan A, Wang J, Lemischka IR. Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nature Cell Biology 2012 Nov; doi: 10.1038/ncb2603
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Fidalgo M, Faiola F, Pereira CF, Ding J, Saunders A, Gingold J, Schaniel C, Lemischka IR, Silva JC, Wang J. Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proc Natl Acad Sci U S A. 2012 Oct 2; doi: 10.1073/pnas.1208533109
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Fidalgo M, Guerrero A, Fraile M, Iglesias C, Pombo CM, Zalvide J. Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress. J Biol Chem. 2012 Mar 30; doi: 10.1074/jbc.M111.320259
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Hernández G, Lal H, Fidalgo M, Guerrero A, Zalvide J, Force T, Pombo CM. A novel cardioprotective p38-MAPK/mTOR pathway. Exp Cell Res. 2011 Dec 10; doi:10.1016/j.yexcr .2011.09.011
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Fidalgo M*, Shekar PC*, Ang YS, Fujiwara Y, Orkin SH, Wang J. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells. 2011 Nov; doi: 10.1002/stem.736
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Fidalgo M, Fraile M, Pires A, Force T, Pombo C, Zalvide J. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. J Cell Sci. 2010 Apr 15; doi: 10.1242/jcs.061341
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Nogueira E*, Fidalgo M*, Molnar A, Kyriakis J, Force T, Zalvide J, Pombo CM. SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. J Biol Chem. 2008 Jun 6; doi: 10.1074/jbc.M709724200
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