selected publications
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Malik V*, Zang R*, Fuentes-Iglesias A, Huang X, Li D, Fidalgo M, Zhou H, and Wang J. Comparative functional genomics identifies unique molecular features of EPSCs. Life Science Alliance. 2022 Aug 12; doi: 10.26508/lsa.202201608
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Pena-Leon V*, Folgueira C*, Barja-Fernández S*, Pérez-Lois R, Da Silva Lima N, Martin M, Heras V, Martinez-Martinez S, Valero P, Iglesias C, Duquenne M, Al-Massadi O, Beiroa D, Souto Y, Fidalgo M, Sowmyalakshmi R, Guallar D, Cunarro J, Castelao C, Senra A, González-Saenz P, Vázquez-Cobela R, Leis R, Sabio G, Mueller-Fielitz H, Schwaninger M, López M, Tovar S, Casanueva FF, Valjent E, Diéguez C, Prevot V, Nogueiras R#, Seoane LM#. Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21. Nature Metabolism. 2022 Jul 25; doi: 10.1038/s42255-022-00602-z.
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Gonzalez-Rellan MJ*, Novoa E*, da Silva Lima N, Rodriguez A, Veyrat-Durebex C, Seoane S, Porteiro B, Fondevila MF, Fernandez U, Varela-Rey M, Senra A, Iglesias C, Escudero A, Fidalgo M, Guallar D, Perez-Fernandez R, Prevot V, Schwaninger M, López M, Dieguez C, Coppari R, Frühbeck G, Nogueiras R. Hepatic p63 regulates glucose metabolism by repressing SIRT1. Gut. 2022 May 17; doi: 10.1136/gutjnl-2021-326620.
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da Silva Lima N*, Fondevila MF*, Nóvoa E*, Buqué X, Mercado-Gómez M, Gallet S, González-Rellan MJ, Fernandez U, Loyens A, Garcia-Vence M, Chantada-Vazquez MDP, Bravo SB, Marañon P, Senra A, Escudero A, Leiva M, Guallar D, Fidalgo M, Gomes P, Claret M, Sabio G, Varela-Rey M, Delgado TC, Montero-Vallejo R, Ampuero J, López M, Diéguez C, Herrero L, Serra D, Schwaninger M, Prevot V, Gallego-Duran R, Romero-Gomez M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Garcia-Monzon C, Gonzalez-Rodriguez A, Aspichueta P, Nogueiras R. Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function. Journal of Hepatology. 2022 Jan 01; doi: 10.1016/j.jhep.2021.09.008. Epub 2021 Sep 21
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Covelo-Molares H*, Souto Y*, Fidalgo M, Guallar D. A Simple, Rapid, and Cost-Effective Method for Loss-of-Function Assays in Pluripotent Cells. Methods Mol Biol.. 2021 Oct 06; doi: 10.1007/7651_2021_434
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Gonzalez-Rellan MJ, Fondevila MF*, Fernandez U*, Rodríguez A, Varela-Rey M, Veyrat-Durebex C, Seoane S, Bernardo G, Lopitz-Otsoa F, Fernández-Ramos D, Bilbao J, Iglesias C, Novoa E, Ameneiro C, Senra A, Beiroa D, Cuñarro J, Chantada-Vazquez MDP, Garcia-Vence M, Bravo SS, Da Silva Lima N, Porteiro B, Carneiro C, Vidal A, Tovar S, Müller TD, Ferno J, Guallar D, Fidalgo M, Sabio G, Herzig S, Yang WH, Cho JW, Martinez-Chantar ML, Perez-Fernandez R, López M, Dieguez C, Mato JM, Millet O, Coppari R, Woodhoo A, Fruhbeck G, Nogueiras R. O-GlcNAcylated p53 in the liver modulates hepatic glucose production. Nature Communications.. 2021 Aug 20; doi:10.1038/s41467-021-25390-0
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Wang Y*, Yu H*, Ma Q*, Zeng P, Wu D, Hou Y, Liu X, Jia L, Sun J, Chen Y, Guallar D, Fidalgo M, Chen J, Yu Y, Jiang S, Li F, Zhao C, Huang X, Wang J, Li C, Sun Y, Zeng X, Zhang W, Miao Y, Ding J. Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions. Cell Stem Cell.. 2021 May 25; doi:10.1016/j.stem.2021.04.023
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Fuentes-Iglesias A*, Ameneiro C*, Guallar D, Fidalgo M. Detecting and Modulating ER Stress to Improve Generation of Induced Pluripotent Stem Cells. Methods Mol Biol.. 2021 Mar 11; doi:10.1007/7651_2021_354
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Garcia-Outeiral V, De La Parte C, Fidalgo M, Guallar D. The complexity of TET2 functions in pluripotency and development. Front. Cell Dev. Biol. 2021 January 18; doi:10.3389/fcell.2020.630754
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Lan J, Rajan N, Bizet M, Penning A, Singh NK, Guallar D, Calonne E, Li Greci A, Bonvin E, Deplus R, Hsu PJ, Nachtergaele S, Ma C, Song R, Fuentes-Iglesias A, Hassabi B, Putmans P, Mies F, Menschaert G, Wong JJL, Wang J, Fidalgo M, Yuan B, Fuks F. Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nature Communications 2020 October 02; doi:10.1038/s41467-020-18729-6
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Fuentes-Iglesias A, Garcia-Outeiral V, Pardavila JA, Wang J#, Fidalgo M#, Guallar D#. An optimized immunoprecipitation protocol for assessing protein-RNA interactions in vitro. STAR Protocols. 2020 September 04; doi: 10.1016/j.xpro.2020.100093
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Guallar D*#, Fuentes-Iglesias A*, Souto Y, Ameneiro C, Freire-Agulleiro O, Pardavila JA, Saenz C, Escudero A, Garcia-Outeiral V, Xiong H, Moreira T, Liu D, Xiao S, Hou Y, Wu K, Torrecilla D, Hartner JC, Blanco MG, Lee LJ, López M, Walkley CR, Wang J#, Fidalgo M#. ADAR1-dependent RNA editing promotes MET and iPSC reprogramming by alleviating ER stress. Cell Stem Cell 2020 May 11; doi: 10.1016/j.stem.2020.04.016
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Fondevila MF, Fernandez U*, Gonzalez-Rellan MJ*, Da Silva Lima N*, Buque X*, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R. The L-α-lysophosphatidylinositol/GPR55 system induces the development of non-alcoholic steatosis and steatohepatitis. Hepatology. 2020 Apr 23; doi: 10.1002/hep.31290
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